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KMID : 1123920020160061190
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 6 p.1190 ~ p.1196
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Study on Selective Anti-cancer Effects by the Water-extracts of Selaginella Tamariscina in Cancer Cell lines
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Lee Sung-Won
Ahn Seong-Hun
Kwak Gun-Shin
Kwak Sup
Lee Jang-Cheon
Mun Yeun-Ja
Woo Won-Hong
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Abstract
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Selaginella Tamariscina is widely used in the traditional oriental herbal medicine for its anti-inflammatory, anti-cancer effects. The effects of aqueous extracts of Selaginella Tamariscina (ST) on the cell viability and induction of apoptotic cell death were investigated in A549, Raw 264.7, C6-glioma. Jurkat and HL-60 cells. The cell viability after treating with extract of Selaginella Tamariscina was quantified by MTT assay method. The results showed that ST decreased the cell viability in HL-60 and Jurkat cells not in A549, Raw 264.7 and C6-glioma cells. And we also observed the chromatin condensation and DNA fragmentation in HL-60 and Jurkat cells. The enzyme activity of caspase-3, tightly regulated by an apoptosis activating complex, were markedly increased in HL-60 cells treated with the ST by dose-dependent manner. In conclusion, our results suggest that the extract of Selaginella Tamariscina may induce the selective apoptotic cell death in HL-60 and Jurkat cells via activation of caspase-3.
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KEYWORD
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Selaginella Tamariscina (ST), apoptosis, caspase-3, DNA fragementaion
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